I am encountering an issue when launching the runtime using the PLC M221 simulation in EcoStruxure Machine Expert with Modbus TCP/IP communication.

Hello Mohamed,

Do you have any specific information about the error you are receiving "TCPServer: Unable to create a channel (Port: 51234) – Error: 10013. Check if this port is already used by another server?" - Perhaps a screen capture of the issue?.

Not quite sure which components you are having issues with, but maybe a look at using netstat to ensure we are not duplicating usage of a port. This should help you narrow down what resources are conflicting and modify the appropriate settings. Would suggest if you need more assistance would recommend to reach out to the Schneider Electric/AVEVA support teams for more details.

https://learn.microsoft.com/en-us/windows-server/administration/windows-commands/netstat